Difference between revisions 6001785 and 6001786 on simplewiki

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===Pharmaceutical===
Ferrocene derivatives have been investigated as drugs.<ref>{{cite journal|first1=Dave R. |last1=Van Staveren |first2=Nils |last2=Metzler-Nolte |title=Bioorganometallic Chemistry of Ferrocene |journal=[[Chemical Reviews|Chem. Rev.]]|date= 2004 |volume=104 |pages=5931–5986
|DOI=10.1021/cr0101510}}</ref> Only one drug has entered the clinic, 
fFerrocenerone, used to treat some cases of iron-deficiency. Though no evidence of the existance of this drug can be found in the lituraturequine, an [[antimalarial]].

[[Image:Ferroquine.png|thumb|220 px|Ferroquine is a commercial antimalarial drug containing a ferrocene group.]]
The anticancer activity of ferrocene derivatives was first investigted in the late 1970s, when derivatives bearing [[amine]] or [[amide]] groups were tested against lymphocytic [[leukemia]].<ref name=":0">{{Cite journal|last=Ornelas|first=Catia|title=Application of ferrocene and its derivatives in cancer research|journal=New Journal of Chemistry|volume=35|doi=10.1039/c1nj20172g}}</ref> Some ferrocenium salts exhibit anticancer activity, but no compound has seen evaluation in the clinic.<ref name="Babin">[No evidence in literature] >Babin, V. N., et al., "Ferrocenes as potential anticancer drugs. Facts and hypotheses", Russ. Chem. Bull. 2014, volume 63, 2405-2422. {{DOI|10.1007/s11172-014-0756-7}}</ref>  An experimental drug was reported which is a ferrocenyl version of [[tamoxifen]].<ref name = top2003 />  The idea is that the tamoxifen will bind to the [[estrogen]] binding sites, resulting in cytotoxicity.<ref name=top2003>{{cite journal|first1=S. |last1=Top |first2=A. |last2=Vessières |first3=G. |last3=Leclercq |first4=J. |last4=Quivy |first5=J. |last5=Tang |first6=J. |last6=Vaissermann|first7= M. |last7=Huché |first8=G. |last8=Jaouen| title=Synthesis, Biochemical Properties and(contracted; show full)
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[[Category:Organoiron compounds]]
[[Category:Metallocenes]]
[[Category:Antiknock agents]]
[[Category:Sandwich compounds]]
[[Category:Cyclopentadienyl complexes]]