Difference between revisions 229827 and 229830 on testwiki

{{GNF_Protein_box
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein transferase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0015631 |text = tubulin binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}} {{GNF_GO|id=GO:0031625 |text = ubiquitin protein ligase binding}} {{GNF_GO|id=GO:0044212 |text = transcription regulatory region DNA binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}{{GNF_GO|id=GO:2000969 |text = positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity}} | Name = Breast cancer 1, early onset
 | image = Protein_BRCA1_PDB_1jm7.png
 | image_source = [[Protein Data Bank|PDB]] rendering based on 1jm7.
 | PDB = {{PDB2|1JM7}}, {{PDB2|1JNX}}, {{PDB2|1N5O}}, {{PDB2|1OQA}}, {{PDB2|1T15}}, {{PDB2|1T29}}, {{PDB2|1T2U}}, {{PDB2|1T2V}}, {{PDB2|1Y98}}, {{PDB2|2ING}}, {{PDB2|3COJ}}, {{PDB2|3K0H}}, {{PDB2|3K0K}}, {{PDB2|3K15}}, {{PDB2|3K16}}, {{PDB2|3PXA}}, {{PDB2|3PXB}}, {{PDB2|3PXC}}, {{PDB2|3PXD}}, {{PDB2|3PXE}}, {{PDB2|4IFI}}, {{PDB2|4IGK}}
 | HGNCid = 1100
 | MGIid = 104537
 | Symbol = BRCA1
 | AltSymbols =; BRCAI; BRCC1; BROVCA1; IRIS; PNCA4; PPP1R53; PSCP; RNF53
 | IUPHAR = 
 | ChEMBL = 5990
 | OMIM = 113705
 | ECnumber = 
 | Homologene = 5276
 | GeneAtlas_image1 = PBB_GE_BRCA1_204531_s_at.png
 | GeneAtlas_image2 = PBB_GE_BRCA1_211851_x_at.png
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 | GeneAtlas_image3 = 
 | Protein_domain_image = 
 | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein transferase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0015631 |text = tubulin binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}} {{GNF_GO|id=GO:0031625 |text = ubiquitin protein ligase binding}} {{GNF_GO|id=GO:0044212 |text = transcription regulatory region DNA binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
 | Component = {{GNF_GO|id=GO:0000151 |text = ubiquitin ligase complex}} {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005694 |text = chromosome}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005925 |text = focal adhesion}} {{GNF_GO|id=GO:0008274 |text = gamma-tubulin ring complex}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}} {{GNF_GO|id=GO:0031436 |text = BRCA1-BARD1 complex}} {{GNF_GO|id=GO:0031941 |text = filamentous actin}} {{GNF_GO|id=GO:0043234 |text = protein complex}} {{GNF_GO|id=GO:0070531 |text = BRCA1-A complex}}
 | Process = {{GNF_GO|id=GO:0000724 |text = double-strand break repair via homologous recombination}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006301 |text = postreplication repair}} {{GNF_GO|id=GO:0006302 |text = double-strand break repair}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006359 |text = regulation of transcription from RNA polymerase III promoter}} {{GNF_GO|id=GO:0006633 |text = fatty acid biosynthetic process}} {{GNF_GO|id=GO:0006915 |text = apoptotic process}} {{GNF_GO|id=GO:0006974 |text = cellular response to DNA damage stimulus}} {{GNF_GO|id=GO:0006978 |text = DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0008630 |text = intrinsic apoptotic signaling pathway in response to DNA damage}} {{GNF_GO|id=GO:0010212 |text = response to ionizing radiation}} {{GNF_GO|id=GO:0016567 |text = protein ubiquitination}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0031398 |text = positive regulation of protein ubiquitination}} {{GNF_GO|id=GO:0031572 |text = G2 DNA damage checkpoint}} {{GNF_GO|id=GO:0034446 |text = substrate adhesion-dependent cell spreading}} {{GNF_GO|id=GO:0035066 |text = positive regulation of histone acetylation}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptotic process}} {{GNF_GO|id=GO:0043627 |text = response to estrogen}} {{GNF_GO|id=GO:0045717 |text = negative regulation of fatty acid biosynthetic process}} {{GNF_GO|id=GO:0045739 |text = positive regulation of DNA repair}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-templated}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-templated}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0046600 |text = negative regulation of centriole replication}} {{GNF_GO|id=GO:0051571 |text = positive regulation of histone H3-K4 methylation}} {{GNF_GO|id=GO:0051573 |text = negative regulation of histone H3-K9 methylation}} {{GNF_GO|id=GO:0051865 |text = protein autoubiquitination}} {{GNF_GO|id=GO:0070512 |text = positive regulation of histone H4-K20 methylation}} {{GNF_GO|id=GO:0071158 |text = positive regulation of cell cycle arrest}} {{GNF_GO|id=GO:0071681 |text = cellular response to indole-3-methanol}} {{GNF_GO|id=GO:0085020 |text = protein K6-linked ubiquitination}} {{GNF_GO|id=GO:2000145 |text = regulation of cell motility}} {{GNF_GO|id=GO:2000617 |text = positive regulation of histone H3-K9 acetylation}} {{GNF_GO|id=GO:2000620 |text = positive regulation of histone H4-K16 acetylation}}
 | Hs_EntrezGene = 672
 | Hs_Ensembl = ENSG00000012048
 | Hs_RefseqmRNA = NM_007294
 | Hs_RefseqProtein = NP_009225
 | Hs_GenLoc_db = hg19
 | Hs_GenLoc_chr = 17
 | Hs_GenLoc_start = 41196312
 | Hs_GenLoc_end = 41277500
 | Hs_Uniprot = P38398
 | Mm_EntrezGene = 12189
 | Mm_Ensembl = ENSMUSG00000017146
 | Mm_RefseqmRNA = NM_009764
 | Mm_RefseqProtein = NP_033894
 | Mm_GenLoc_db = mm10
 | Mm_GenLoc_chr = 11
 | Mm_GenLoc_start = 101488764
 | Mm_GenLoc_end = 101551955
 | Mm_Uniprot = P48754
 | path = PBB/672
}}