Difference between revisions 229840 and 309164 on testwiki

{{PBB|geneid=5649}}
'''Reelin''' is a large secreted [[extracellular matrix]] [[glycoprotein]] that helps regulate processes of [[neuronal migration]] and positioning in the developing brain by controlling [[cell–cell interaction]]s. Besides this important role in early [[Developmental biology|development]], reelin continues to work in the adult brain. It modulates [[synaptic plasticity]] by enhancing the induction and maintenance of [[long-term potentiation]].<ref name=&quo(contracted; show full)
The primary phenotype associated with loss of reelin function is a failure of neuronal positioning throughout the developing [[central nervous system]] (CNS). The mice [[Zygosity|heterozygous]] for the reelin gene, while having little neuroanatomical defects, display the [[endophenotype|endophenotypic]] traits linked to psychotic disorders.<ref name="pmid16769115" />

== Discovery ==
[[File:Reeler 100kbps.og
gv|230px|thumb|left|Video: the reeler mice mutants, first described in 1951 by [[D.S.Falconer]], were later found to lack reelin protein.]]

[[File:Reeler lamination.png|thumb|250px|Normal and [[Reeler]] mice brain slices.]]
(contracted; show full){{Use dmy dates|date=November 2010}}

[[Category:EC 3.4.21|*]]
[[Category:Molecular neuroscience]]
[[Category:Neurology]]
[[Category:Glycoproteins]]
[[Category:Biology of bipolar disorder]]
[[Category:Articles containing video clips]]