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Zerona
{{cleanup|date=April 2011}}{{More footnotes|article|date=July 2011}}
'''Zerona''' is a low-level laser device applied for non-invasive body slimming of the waist, hips, and thighs.  It has been shown to disrupt [[adipocyte]], or fat cell, membranes causing the release of stored [[lipids]] and fatty material, in turn, promoting adipocyte collapse.  The device was first introduced to the market in 2008 as an [[off-label use]] device for slimming, but later was granted 510k market clearance by the [[Food and Drug Administration]] in 2010 indicated for use as a non-invasive dermatological aesthetic treatment for the reduction of circumference of hips, waist, and thighs.  The Zerona was the first aesthetic device to receive this indication by the FDA following the completion of a [[placebo-controlled]], randomized, [[double-blind]], multi-centered [[clinical trial]].  Clinical study participants randomly assigned to receive “active” or real treatment displayed an average loss of 3.5&nbsp;inches or 8.89 centimeters{{Convert|3.5|in|cm|abbr=on}} across the waist, hips, and thighs in two weeks.  This was compared to study participants randomly assigned to the “sham” or [[placebo]] group who exhibited a reduction of 0.68&nbsp;inches or 1.72 centimeters{{Convert|0.68|in|cm|abbr=on}} after two weeks.<ref name=pmid20014253>{{cite journal |pmid=20014253 |first1=Robert F. |last1=Jackson |first2=Doug D. |last2=Dedo |first3=Greg C. |last3=Roche |first4=David I. |last4=Turok |first5=Ryan J. |last5=Maloney |year=2009 |url=http://www.erchonia.com/files/uploads/1/file/Jackson_3LT%20Non-Invasive%20Approach%20for%20Body%20Contouring%20Randomized%20Controlled%20Study_LISM_12_09.pdf |title=Low-Level Laser Therapy as a Non-Invasive Approach for Body Contouring: A Randomized, Controlled Study |(contracted; show full)

31.)	Jackson et al.  Reductions in cholesterol and triglyceride serum levels following low level laser irradiation: A non-controlled, non-randomized pilot study.  Amer J Cosmet Surg. 2010;27(4):177-184.

32.)    Coleman et al. Clinical Efficacy of Non-Invasive Cryolipolysis and its Effects on Peripheral Nerves. Aest Plast Surg, DOI 10.1007/s00266-008-9286-8

[[Category:Laser medicine]]