Difference between revisions 439297822 and 439298067 on enwiki

{{cleanup|date=April 2011}}{{More footnotes|article|date=July 2011}}
'''Zerona''' is a low-level laser device applied for non-invasive body slimming of the waist, hips, and thighs.  It has been shown to disrupt [[adipocyte]], or fat cell, membranes causing the release of stored [[lipids]] and fatty material, in turn, promoting adipocyte collapse.  The device was first introduced to the market in 2008 as an [[off-label use]] device for slimming, but later was granted 510k market(contracted; show full)mical gradient]].  Cytochrome c oxidase serves an important role in the metabolic process known as [[oxidative phosphorylation]], which is the production of the high energy molecule [[adenosine triphosphate]] (ATP).<ref>{{cite book |first1=Reginald |last1=Garrett |first2=Charles M. |last2=Grisham |title=Biochemistry |edition=3rd |year=2010 |isbn=978-0-495-10935-8 |url=http://books.google.com/books?id=iGPsen3fSOIC}}{{Page needed|date=July 2011}}</ref><ref name=pmid6479342>{{cite journal |p
mid=6479342 |year=1984 |last1=Passarella |first1=S |last2=Casamassima |first2=E |last3=Molinari |first3=S |last4=Pastore |first4=D |last5=Quagliariello |first5=E |last6=Catalano |first6=IM |last7=Cingolani |first7=A |title=Increase of proton electrochemical potential and ATP synthesis in rat liver mitochondria irradiated in vitro by helium-neon laser |volume=175 |issue=1 |pages=95–9 |journal=FEBS letters |doi=10.1016/0014-5793(84)80577-3}}</ref><ref name=pmid2476986>{{cite journal |pmid=2476986 |year=1989 |last1=Greco |first1=M |last2=Guida |first2=G |last3=Perlino |first3=E |last4=Marra |first4=E |last5=Quagliariello |first5=E |title=Increase in RNA and protein synthesis by mitochondria irradiated with helium-neon laser |volume=163 |issue=3 |pages=1428–34 |journal=Biochemical and biophysical research communicationsages=95–9 |doi=10.1016/0014-5793(84)80577-3}}</ref><ref name=pmid2476986>{{cite journal |pages=1428–34 |doi=10.1016/0006-291X(89)91138-8}}</ref> Stimulation of cytochrome c oxidase with a well-defined monochromatic low-level laser instrument modulates cellular metabolism and secondary biological cascades which can affect cell function and behavior giving rise to the positive clinical outcomes that have been reported.<ref name=pmc2790317/>  Subsequent to laser stimulation the mitochondrial membrane potential and proton gradient increases, prompting changes in mitochondria optical properties and increasing the rate of ADP/ATP exchange.<ref>{{cite journal |pmid=16144476 |year=2005 |last1=Karu |first1=TI |last2=Kolyakov |first2=SF |title=Exact action spectra for cellular responses relevant to phototherapy |volume=23 |issue=4 |pages=355–61 |doi=10.1089/pho.2005.23.355 |journal=Photomedicine and laser surgeryages=355–61 |doi=10.1089/pho.2005.23.355}}</ref><ref>{{cite book |first1=Aleksandr Nikolaevich |last1=Terenin |year=1954 |title=Photochemistry of dyes and related organic compounds |oclc=32060439}}{{Page needed|date=July 2011}}</ref><ref>{{cite journal |pages=265–322 |doi=10.1016/0304-4173(85)90014-X |title=Electron transfers in chemistry and biology |year=1985 |last1=Marcus |first1=R |journal=Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics |volume=811 |issue=3}}</ref> It is suggested that laser irradiation increases the rate at which cytochrome c oxidase transfers electrons from cytochrome c to dioxygen.<ref>{{cite journal |pmid=6479342 |year=1984 |last1=Passarella |first1=S |last2=Casamassima |first2=E |last3=Molinari |first3=S |last4=Pastore |first4=D |last5=Quagliariello |first5=E |last6=Catalano |first6=IM |last7=Cingolani |first7=A |title=Increase of proton electrochemical potential and ATP synthesis in rat liver mitochondria(contracted; show full)

31.)	Jackson et al.  Reductions in cholesterol and triglyceride serum levels following low level laser irradiation: A non-controlled, non-randomized pilot study.  Amer J Cosmet Surg. 2010;27(4):177-184.

32.)    Coleman et al. Clinical Efficacy of Non-Invasive Cryolipolysis and its Effects on Peripheral Nerves. Aest Plast Surg, DOI 10.1007/s00266-008-9286-8

[[Category:Laser medicine]]