Difference between revisions 439336104 and 439339299 on enwiki

{{cleanup|date=April 2011}}{{More footnotes|article|date=July 2011}}
'''Zerona''' is a low-level laser device applied for non-invasive body slimming of the waist, hips, and thighs.  It has been shown to disrupt [[adipocyte]], or fat cell, membranes causing the release of stored [[lipids]] and fatty material, in turn, promoting adipocyte collapse.  The device was first introduced to the market in 2008 as an [[off-label use]] device for slimming, but later was granted 510k market(contracted; show full)
The exact mechanism of action for the Zerona is not fully-understood.  As a low-level laser device the theory of action is defined as bioorganic [[photochemistry]], a discipline that explores the interaction between [[photons]] and biochemical pathways within cells.  Like many other science principles, bioorganic photochemistry is defined by laws, and the first law of [[photochemistry]] states that a photoabsorbing structure must be present to yield a clinical outcome. [[Cytochrome c oxidase]]
  , a terminal enzyme found within the [[electron transport chain]] of the [[mitochondria]]  , has been reported{{by whom}} to function as a photoabsorbing complex within eukaryotic cells ([[eukaryote]]).  {{fact}} This enzyme is responsible for facilitating the transport of electrons across the [[inner mitochondrial membrane]] to reduce oxygen and generate a proton [[electrochemical gradient]].   Cytochrome c oxidase serves an important role in the metabolic process known as [[oxidative phosphorylation]], which is the production of the high energy molecule [[adenosine triphosphate]] (ATP).<ref>{{cite book |first1=Reginald |last1=Garrett |first2=Charles M. |last2=Grisham |title=Biochemistry |edition=3rd |year=2010 |isbn=978-0-495-10935-8 |url=http://books.google.com/books?id=iGPsen3fSOIC}}{{Page needed|date=July 201chapter=Electron Transport and Oxidative Phosphorylation |title=Biochemistry |edition=3rd |year=2005 |pages=640–73 |isbn=978-0-534-49033-1}}</ref><ref name=pmid6479342>{{cite journal |pages=95–9 |doi=10.1016/0014-5793(84)80577-3 |title=Increase of proton electrochemical potential and ATP synthesis in rat liver mitochondria irradiated in vitro by helium-neon laser |year=1984 |last1=Passarella |first1=S. |last2=Casamassima |first2=E. |last3=Molinari |first3=S. |last4=Pastore |first4=D. |last5=Quagliariello |first5=E. |last6=Catalano |first6=I.M. |last7=Cingolani |first7=A. |journal=FEBS Letters |volume=175 |pmid=6479342 |issue=1}}&(contracted; show full)evel Laser Irradiation: A Noncontrolled, Nonrandomized Pilot Study |journal=The American Journal of Cosmetic Surgery |volume=27 |issue=4 |pages=177–84 |url=http://www.erchonia.com/files/uploads/1/file/Jackson_Reduction%20in%20Cholesterol%20and%20Triglyceride%20Serum%20Levels%20Following%203LT_AJCS_2010.pdf}}</ref> Presently, clinical studies are on-going to elucidate the potential utility of this application.{{Citation needed|date=July 2011}}

== References ==
{{reflist}}

[[Category:Laser medicine]]