Difference between revisions 6001795 and 6001796 on simplewiki

{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 457631192
| ImageFileL1 = Ferrocene.svg
| ImageSizeL1 = 80 px
| ImageFileR1 = Ferrocene-from-xtal-3D-balls.png
| ImageSizeR1 = 80 px
(contracted; show full)
|DOI=10.1021/cr0101510}}</ref> Only one drug has entered the clinic, Ferroquine, an [[antimalarial]].

[[Image:Ferroquine.png|thumb|220 px|Ferroquine is a commercial antimalarial drug containing a ferrocene group.]]
The anticancer activity of ferrocene derivatives was first investig
ated in the late 1970s, when derivatives bearing [[amine]] or [[amide]] groups were tested against lymphocytic [[leukemia]].<ref name=":0">{{Cite journal|last=Ornelas|first=Catia|title=Application of ferrocene and its derivatives in cancer research|journal=New Journal of Chemistry|volume=35|doi=10.1039/c1nj20172g}}</ref> Some ferrocenium salts exhibit anticancer activity, but no compound has seen evaluation in the clinic.<ref name=Babin>Babin, V. N., et al., "Ferrocenes as po(contracted; show full)t;{{cite journal|first = Rudolf|last = Pietschnig|title = Polymers with pendant ferrocenes|journal = [[Chemical Society Reviews|Chem. Soc. Rev.]]|year = 2016|volume = 45|pages = 5216–5231|doi = 10.1039/C6CS00196C}}</ref>  Both PVFc and PFcMA have been tethered onto [[silica]] wafers and the [[wettability]] measured when the polymer chains are uncharged and when the ferrocene moieties are oxidised to produce positively charged groups.  The [[contact angle]] with water on the PFcMA-coated wafers was 70
&deg;° smaller following oxidation, while in the case of PVFc the decrease was 30&deg;°, and the switching of wettability is reversible.  In the PFcMA case, the effect of lengthening the chains and hence introducing more ferrocene groups is significantly larger reductions in the contact angle upon oxidation.<ref name = Pietschnig /><ref>{{cite journal|first1 = J.|last1 = Elbert|first2 = M.|last2 = Gallei|first3 = C.|last3 = Rüttiger|first4 = A.|last4 = Brunsen|first5 = H.|last5 = Didzoleit|first6 = B.|last6 = Stühn|first7 = M.|last7 = Rehahn|journal = [[Organometallics]]|year = 2013|volume = 32|issue = 20|pages = 5873–5878|title = Ferrocene Polymers for Switchable Surface Wettability|doi = 10.1021/om400468p}}</ref>

==See also==
* [[Josiphos ligands]]

==References==
{{reflist|30em}}

==External links==
* [http://www.periodicvideos.com/videos/mv_ferrocene.htm Ferrocene] at ''[[The Periodic Table of Videos]]'' (University of Nottingham)
* [http://www.cdc.gov/niosh/npg/npgd0205.html NIOSH Pocket Guide to Chemical Hazards] (Centers for Disease Control and Prevention)

{{commons category|ferrocene}}

{{Authority control}}

[[Category:Organoiron compounds]]
[[Category:Metallocenes]]
[[Category:Antiknock agents]]
[[Category:Sandwich compounds]]
[[Category:Cyclopentadienyl complexes]]